ncRNA name | CRABP-II siRNA |
ncRNA Category | siRNA |
Disease name | autoimmune uveitis |
Species | Mus musculus |
Tissues/Cell_line | RPE cells |
Methods | flow cytometry, ELISA, microarray, qRT-PCR, siRNA transfection |
Expression pattern | associated |
Functional description | Our data support the hypothesis that RPE cells produce RA, thereby enabling bystander T cells to be converted into Tregs through TGFβ promotion, which can then participate in the establishment of immune tolerance in the eye. RA receptor antagonist-pretreated or RA-binding protein-siRNA-transfected RPE cells failed to convert CD4(+) T cells into Tregs. |
PubMed ID | 22116001 |
Year | 2012 |
Title | Retinoic acid from retinal pigment epithelium induces T regulatory cells. |
Drug-related ncRNA | NO |
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